Tuberin/TSC2 (Phospho Ser1254) rabbit pAb

  • Catalog No.：YP1538
  • Applications：WB
  • Reactivity：Human;Mouse;Rat
    • Target：
    • Tuberin
    • Fields：
    • >>Phospholipase D signaling pathway;>>p53 signaling pathway;>>Autophagy - animal;>>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Cellular senescence;>>Thermogenesis;>>Insulin signaling pathway;>>Thyroid hormone signaling pathway;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Herpes simplex virus 1 infection;>>Choline metabolism in cancer
    • Gene Name：
    • TSC2 TSC4
    • Protein Name：
    • Tuberin/TSC2 (Ser1254)
    • Human Gene Id：
    • 7249
    • Human Swiss Prot No：
    • P49815
    • Mouse Swiss Prot No：
    • Q61037
    • Immunogen：
    • Synthesized phosho peptide around human Tuberin(Ser1254)
    • Specificity：
    • This antibody detects endogenous levels of Human Mouse Rat Tuberin/TSC2 (phospho-Ser1254)
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:1000-2000
    • Purification：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Tuberin (Tuberous sclerosis 2 protein)
    • Observed Band(KD)：
    • 200kD
    • Background：
    • Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
    • Function：
    • alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,disease:Defects in TSC2 are a cause of lymphangioleiomyomatosis (LAM) [MIM:606690]. LAM is a progressive and often fatal lung disease characterized by a diffuse proliferation of abnormal smooth muscle cells in the lungs. It affects almost exclusively young women and can occur as an isolated disorder or in association with tuberous sclerosis complex.,disease:Defects in TSC2 are the cause of tuberous sclerosis complex (TSC) [MIM:191100]. The molecular basis of TSC is a functional impairment of the tuberin-hamartin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. TSC is characterized by hamartomas (benign overgrowths predominantly of a cell or tissue type that occurs normally in the organ) and hamartias (de
    • Subcellular Location：
    • Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes.
    • Expression：
    • Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.

    Attributes

    • Code：
    • YP1538
    • Size
    • 50μL / 100μL / 200μL
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-12-26
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