p57kip2 (ABT214) IHC kit

  • Catalog No.：IHCM6996
  • Applications：IHC
  • Reactivity：Human;Mouse;Rat;
    • Target：
    • p57
    • Fields：
    • >>Cell cycle
    • Gene Name：
    • CDKN1C KIP2
    • Protein Name：
    • Beckwith Wiedemann syndrome;BWCR;BWS;CDKI;CDKN 1C;CDKN1C;CDN1C_HUMAN;Cyclin dependent kinase inhibitor 1C;Cyclin dependent kinase inhibitor p57;Cyclin-dependent kinase inhibitor 1C;Cyclin-dependent ki
    • Human Swiss Prot No：
    • P49918
    • Mouse Swiss Prot No：
    • P49919
    • Immunogen：
    • Synthesized peptide derived from human p57kip2 AA range: 200-316
    • Specificity：
    • The antibody can specifically recognize human p57kip2 protein.
    • Source：
    • Mouse, Monoclonal/IgG2b, kappa
    • Purification：
    • The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
    • Storage Stability：
    • 2°C to 8°C/1 year
    • Other Name：
    • Beckwith Wiedemann syndrome;BWCR;BWS;CDKI;CDKN 1C;CDKN1C;CDN1C_HUMAN;Cyclin dependent kinase inhibitor 1C;Cyclin dependent kinase inhibitor p57;Cyclin-dependent kinase inhibitor 1C;Cyclin-dependent kinase inhibitor p57;KIP 2;KIP2;p57;p57 Kip 2;p57KIP2;WBS
    • Background：
    • This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010],
    • Function：
    • disease:Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.,disease:Defects in CDKN1C are involved in tumor formation.,function:Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.,similarity:Belongs to the CDI family.,tissue specificity:Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels ar
    • Subcellular Location：
    • Nuclear
    • Expression：
    • Placenta/ Kindey

    Attributes

    • Code：
    • IHCM6996
    • Size
    • 3mL / 10mL / 100mL
    • Price$：
    • 156 / 356 / 2960
    • Delivery：
    • 2024-11-30
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