Phospho Adrenergic Receptor β2 (S346) Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA1511C
  • Applications：ELISA
  • Reactivity：Human
    • Gene Name：
    • ADRB2
    • Human Gene Id：
    • 154
    • Human Swiss Prot No：
    • P07550
    • Mouse Swiss Prot No：
    • P18762
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)
    • Detection Method：
    • Colorimetric
    • Background：
    • disease:Polymorphic forms of ADRB2 could impart some form of nocturnal asthma.,function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.,PTM:Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation.,PTM:Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK. Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Binds SLC9A3R1 and GPRASP1.,
    • Function：
    • temperature homeostasis, tissue homeostasis, regulation of systemic arterial blood pressure by norepinephrine-epinephrine, response to dietary excess, diet induced thermogenesis, vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure, regulation of sodium ion transport, desensitization of G-protein coupled receptor protein signaling pathway, desensitization of G-protein coupled receptor protein signaling pathway by arrestin, circulatory system process, vascular process in circulatory system, regulation of systemic arterial blood pressure mediated by a chemical signal, regulation of systemic arterial blood pressure, negative regulation of systemic arterial blood pressure, regulation of nucleotide metabolic process, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein complex assembly
    • Subcellular Location：
    • Cell membrane ; Multi-pass membrane protein . Early endosome . Golgi apparatus . Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325). Activated receptors are also detected within the Golgi apparatus (PubMed:27481942). .

    Attributes

    • Code：
    • KA1511C
    • Size
    • 96 / well
    • Price$：
    • 470
    • Delivery：
    • 2024-12-09
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