Phospho RIPK2 (S176) Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA1721C
  • Applications：ELISA
  • Reactivity：Human;Mouse
    • Gene Name：
    • RIPK2
    • Human Gene Id：
    • 8767
    • Human Swiss Prot No：
    • O43353
    • Mouse Swiss Prot No：
    • P58801
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
    • Detection Method：
    • Colorimetric
    • Background：
    • catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappa-B.,PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 CARD domain.,similarity:Contains 1 protein kinase domain.,subunit:Binds to CFLAR/CLARP and CASP1 via their CARD domains. Binds to BIRC3/c-IAP1 and BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5 and TRAF6. May be a component of both the TNFRSF1A and TNRFSF5/CD40 receptor complex.,tissue specificity:Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.,
    • Function：
    • cell activation, regulation of cytokine production, positive regulation of cytokine production, activation of innate immune response, pattern recognition receptor signaling pathway, toll-like receptor signaling pathway, response to molecule of bacterial origin, activation of immune response, immune response-activating cell surface receptor signaling pathway, positive regulation of immune system process, regulation of leukocyte activation, positive regulation of leukocyte activation, immune response-activating signal transduction, innate immune response-activating signal transduction, immune response-regulating signal transduction, immune response-regulating cell surface receptor signaling pathway, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process,apoptosis, anti-apoptosis, defense response, inflammatory response, cell surface receptor linked si
    • Subcellular Location：
    • Cytoplasm .
    • Expression：
    • Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.

    Attributes

    • Code：
    • KA1721C
    • Size
    • 96 / well
    • Price$：
    • 470
    • Delivery：
    • 2024-12-08
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