• Gene Name：
• SYP

• Human Gene Id：
• 6855

• Human Swiss Prot No：
• P08247

• Mouse Swiss Prot No：
• Q62277

• Rat Swiss Prot No：
• P07825

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• Synaptophysin (Major synaptic vesicle protein p38)

• Detection Method：
• Colorimetric

• Background：
• domain:The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.,function:Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane.,online information:Synaptophysin entry,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the synaptophysin/synaptobrevin family.,similarity:Contains 1 MARVEL domain.,subunit:Homohexamer or homotetramer.,tissue specificity:Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.,

• Function：
• endocytosis, endomembrane organization, membrane invagination, membrane organization, vesicle organization,synaptic vesicle maturation, vesicle-mediated transport, developmental maturation, regulation of neurological system process, regulation of system process, regulation of synaptic plasticity, regulation of neuronal synaptic plasticity,regulation of long-term neuronal synaptic plasticity, regulation of short-term neuronal synaptic plasticity, synaptic vesicle endocytosis, synaptic vesicle transport, synaptic vesicle membrane organization, regulation of synaptic transmission, regulation of transmission of nerve impulse,

• Subcellular Location：
• Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Cell junction, synapse, synaptosome .

• Expression：
• Expressed in the brain, with expression in the hippocampus, the neuropil in the dentate gyrus, where expression is higher in the outer half of the molecular layer than in the inner half, and in the neuropil of CA4 and CA3 (PubMed:8838578). Expressed in the putamen (at protein level) (PubMed:17296554).

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