Total Synuclein-β Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA3387C
  • Applications：ELISA
  • Reactivity：Human;Mouse;Rat
    • Gene Name：
    • SNCB
    • Human Gene Id：
    • 6620
    • Human Swiss Prot No：
    • Q16143
    • Mouse Swiss Prot No：
    • Q91ZZ3
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Beta-synuclein
    • Detection Method：
    • Colorimetric
    • Background：
    • disease:Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.,function:Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a TP53/p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.,PTM:Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.,similarity:Belongs to the synuclein family.,tissue specificity:Expressed predominantly in brain; concentrated in presynaptic nerve terminals.,
    • Function：
    • cellular amino acid derivative metabolic process, biogenic amine metabolic process, catecholamine metabolic process,catechol metabolic process, regulation of cell death, phenol metabolic process, diol metabolic process, dopamine metabolic process, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death,negative regulation of programmed cell death, regulation of neuron apoptosis, negative regulation of neuron apoptosis, negative regulation of cell death,
    • Subcellular Location：
    • Cytoplasm.
    • Expression：
    • Expressed predominantly in brain; concentrated in presynaptic nerve terminals.

    Attributes

    • Code：
    • KA3387C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-12-08
    Order

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