Total HES-6 Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA3862C
  • Applications：ELISA
  • Reactivity：Human
    • Gene Name：
    • HES6
    • Human Swiss Prot No：
    • Q96HZ4
    • Mouse Swiss Prot No：
    • Q9JHE6
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Transcription cofactor HES-6 (C-HAIRY1) (Class B basic helix-loop-helix protein 41) (bHLHb41) (Hairy and enhancer of split 6)
    • Detection Method：
    • Colorimetric
    • Background：
    • domain:Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).,domain:The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.,function:Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 Orange domain.,subunit:Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Interacts with HES1.,
    • Function：
    • transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter,regulation of transcription, regulation of RNA metabolic process,
    • Subcellular Location：
    • Nucleus .

    Attributes

    • Code：
    • KA3862C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-12-09
    Order

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