Total CYP17A1 Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA3880C
  • Applications：ELISA
  • Reactivity：Human
    • Gene Name：
    • CYP17A1
    • Human Gene Id：
    • 1586
    • Human Swiss Prot No：
    • P05093
    • Mouse Swiss Prot No：
    • P27786
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.99.9) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase)
    • Detection Method：
    • Colorimetric
    • Background：
    • catalytic activity:A steroid + AH(2) + O(2) = a 17-alpha-hydroxysteroid + A + H(2)O.,cofactor:Heme group.,disease:Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5) [MIM:202110]. AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: "salt wasting" (SW, the most severe type), "simple virilizing" (SV, less severely affected patients), with normal aldosterone biosynthesis, "non-classic form" or late onset (NC or LOAH), and "cryptic" (asymptomatic).,enzyme regulation:Regulated predominantly by intracellular cAMP levels.,function:Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.,online information:The Singapore human mutation and polymorphism database,pathway:Lipid metabolism; steroid biosynthesis.,PTM:Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity.,similarity:Belongs to the cytochrome P450 family.,
    • Function：
    • reproductive developmental process, steroid biosynthetic process, glucocorticoid biosynthetic process, sex differentiation, steroid metabolic process, glucocorticoid metabolic process, lipid biosynthetic process, response to toxin, regulation of hormone levels, cellular hormone metabolic process, hormone metabolic process, hormone biosynthetic process, oxidation reduction,
    • Subcellular Location：
    • Endoplasmic reticulum membrane . Microsome membrane .

    Attributes

    • Code：
    • KA3880C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-12-09
    Order

    Related Products