Total CYP19A1 Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA3881C
  • Applications：ELISA
  • Reactivity：Human;Mouse;Rat
    • Gene Name：
    • CYP19A1
    • Human Gene Id：
    • 1588
    • Human Swiss Prot No：
    • P11511
    • Mouse Swiss Prot No：
    • P28649
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Cytochrome P450 19A1 (EC 1.14.14.1) (Aromatase) (CYPXIX) (Cytochrome P-450AROM) (Estrogen synthase)
    • Detection Method：
    • Colorimetric
    • Background：
    • catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,disease:Defects in CYP19A1 are a cause of familial gynecomastia [MIM:139300]. This is characterized by an estrogen excess due to an increased aromatase activity.,disease:Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:107910]. AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.,function:Catalyzes the formation of aromatic C18 estrogens from C19 androgens.,online information:Aromatase entry,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Brain, placenta and gonads.,
    • Function：
    • steroid biosynthetic process, steroid metabolic process, lipid biosynthetic process, oxidation reduction,
    • Subcellular Location：
    • Endoplasmic reticulum membrane ; Multi-pass membrane protein . Microsome membrane ; Multi-pass membrane protein .
    • Expression：
    • Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads.

    Attributes

    • Code：
    • KA3881C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-12-09
    Order

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