• Gene Name：
• CYP2R1

• Human Gene Id：
• 120227

• Human Swiss Prot No：
• Q6VVX0

• Mouse Swiss Prot No：
• Q6VVW9

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• Vitamin D 25-hydroxylase (EC 1.14.13.159) (Cytochrome P450 2R1)

• Detection Method：
• Colorimetric

• Background：
• catalytic activity:5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O(2) = (25R)-5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP(+) + H(2)O.,cofactor:Heme group.,disease:Defects in CYP2R1 are a cause of 25-hydroxyvitamin D(3) deficiency (25HOD3D)[MIM:600081]; also known as pseudovitamin D(3) deficiency rickets due to 25-hydroxylase deficiency. First described in patients who had rickets at a young age despite a history of adequate vitamin D intake. The patients sera had low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activity, and low levels of 25-hydroxyvitamin D.,function:Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).,similarity:Belongs to the cytochrome P450 family.,subunit:Homodimer.,

• Function：
• vitamin metabolic process, fat-soluble vitamin metabolic process, steroid metabolic process, vitamin D metabolic process, oxidation reduction,

• Subcellular Location：
• Endoplasmic reticulum membrane ; Peripheral membrane protein. Microsome membrane ; Peripheral membrane protein.

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