• Gene Name：
• PLA2G4A

• Human Gene Id：
• 5321

• Human Swiss Prot No：
• P47712

• Mouse Swiss Prot No：
• P47713

• Rat Swiss Prot No：
• P50393

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase);Lysophospholipase (EC 3.1.1.5)]

• Detection Method：
• Colorimetric

• Background：
• catalytic activity:2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.,catalytic activity:Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.,domain:The N-terminal C2 domain, by its association with lipid membranes, mediates the regulation of CPLA2 by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).,enzyme regulation:Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+).,function:Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.,PTM:Activated by phosphorylation at both Ser-505 and Ser-727.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PLA2c domain.,subcellular location:Translocates to membrane vesicles in a calcium-dependent fashion.,subunit:Interacts with HTATIP.,tissue specificity:Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.,

• Function：
• very-long-chain fatty acid metabolic process, response to reactive oxygen species, ovulation from ovarian follicle,luteolysis, placenta development, maternal placenta development, tissue homeostasis, response to molecule of bacterial origin, regulation of acute inflammatory response, positive regulation of acute inflammatory response,reproductive developmental process, cellular amino acid derivative metabolic process, biogenic amine metabolic process, fatty acid metabolic process, phospholipid metabolic process, glycerophospholipid metabolic process, platelet activating factor biosynthetic process, icosanoid metabolic process, response to oxidative stress, gamete generation,female gamete generation, sex differentiation, female pregnancy, aging, response to nutrient, positive regulation of cell proliferation, gonad development, female gonad development, lipid biosynthetic process, phospho

• Subcellular Location：
• Cytoplasm . Golgi apparatus membrane . Nucleus envelope. Translocates to intracellular membranes in a calcium-dependent way. .

• Expression：
• Expressed in various cells and tissues such as macrophages, neutrophils, fibroblasts and lung endothelium. Expressed in platelets (at protein level) (PubMed:25102815).

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