Total MAP3K8 Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA4167C
  • Applications：ELISA
  • Reactivity：Human;Mouse;Rat
    • Gene Name：
    • MAP3K8
    • Human Gene Id：
    • 1326
    • Human Swiss Prot No：
    • P41279
    • Mouse Swiss Prot No：
    • Q07174
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2)
    • Detection Method：
    • Colorimetric
    • Background：
    • catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,developmental stage:Isoform 1 is activated specifically during the S and G2/M phases of the cell cycle.,function:Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.,PTM:Autophosphorylated. Isoform 1 undergoes phosphorylation mainly on Ser residues, and isoform 2 on both Ser and Thr residues.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Forms a ternary complex with NFKB1 and TNIP2.,tissue specificity:Expressed in several normal tissues and human tumor-derived cell lines.,
    • Function：
    • protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cell cycle,phosphorylation,
    • Subcellular Location：
    • Cytoplasm .
    • Expression：
    • Expressed in several normal tissues and human tumor-derived cell lines.

    Attributes

    • Code：
    • KA4167C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-08-01
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