• Gene Name：
• SF1

• Human Gene Id：
• 7536

• Human Swiss Prot No：
• Q15637

• Mouse Swiss Prot No：
• Q64213

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162)

• Detection Method：
• Colorimetric

• Background：
• alternative products:Additional isoforms seem to exist,function:Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.,PTM:Phosphorylation on Ser-20 interferes with U2AF2 binding and spliceosome assembly. Isoform 6 is phosphorylated on Ser-463.,similarity:Belongs to the BBP/SF1 family.,similarity:Contains 1 CCHC-type zinc finger.,similarity:Contains 1 KH domain.,subunit:Binds U2AF2. Interacts with U1 snRNA. Binds EWSR1, FUS and TAF15.,tissue specificity:Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart.,

• Function：
• spliceosome assembly, RNA splicing, via transesterification reactions, RNA splicing, via transesterification reactions with bulged adenosine as nucleophile, nuclear mRNA 3'-splice site recognition, nuclear mRNA splicing, via spliceosome,reproductive developmental process, transcription, mRNA splice site selection, RNA processing, mRNA processing, cell cycle, sex determination, sex differentiation, negative regulation of cell proliferation, RNA splicing, gonad development,male gonad development, mRNA metabolic process, regulation of lipid metabolic process, regulation of steroid metabolic process, cell cycle process, ribonucleoprotein complex biogenesis, ribonucleoprotein complex assembly, male sex determination, Leydig cell differentiation, cellular macromolecular complex subunit organization, cellular macromolecular complex assembly, regulation of cell proliferation, macromolecular comp

• Subcellular Location：
• Nucleus.

• Expression：
• Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart.

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