• Gene Name：
• TPH2

• Human Gene Id：
• 121278

• Human Swiss Prot No：
• Q8IWU9

• Mouse Swiss Prot No：
• Q8CGV2

• Rat Swiss Prot No：
• Q8CGU9

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Neuronal tryptophan hydroxylase) (Tryptophan 5-monooxygenase 2)

• Detection Method：
• Colorimetric

• Background：
• catalytic activity:L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.,cofactor:Fe(2+) ion.,disease:Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].,pathway:Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.,similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.,similarity:Contains 1 ACT domain.,tissue specificity:Brain specific.,

• Function：
• cellular amino acid derivative metabolic process, biogenic amine metabolic process, indolalkylamine metabolic process,aromatic amino acid family metabolic process, amine biosynthetic process, heterocycle biosynthetic process, cellular amino acid derivative biosynthetic process, biogenic amine biosynthetic process, serotonin biosynthetic process,serotonin metabolic process, indole and derivative metabolic process, indole derivative metabolic process, indole derivative biosynthetic process, nitrogen compound biosynthetic process, indolalkylamine biosynthetic process,oxidation reduction,

• Expression：
• Brain specific.

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