• Gene Name：
• TNFSF15

• Protein Name：
• Tumor necrosis factor ligand superfamily member 15

• Human Gene Id：
• 9966

• Human Swiss Prot No：
• O95150

• Mouse Swiss Prot No：
• Q5UBV8

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• TNFSF15;TL1;VEGI;Tumor necrosis factor ligand superfamily member 15;TNF ligand-related molecule 1;Vascular endothelial cell growth inhibitor

• Detection Method：
• Colorimetric

• Background：
• function:Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.,induction:Up-regulated by IL-1-alpha and TNF-alpha.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,tissue specificity:Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.,

• Function：
• regulation of cytokine production, regulation of endothelial cell proliferation, negative regulation of endothelial cell proliferation, apoptosis, activation of caspase activity, immune response, intracellular signaling cascade, protein kinase cascade, I-kappaB kinase/NF-kappaB cascade, activation of NF-kappaB-inducing kinase activity, cell death,negative regulation of cell proliferation, regulation of cell death, positive regulation of peptidase activity, programmed cell death, death, regulation of phosphate metabolic process, activation of protein kinase activity, regulation of protein localization, positive regulation of kinase activity, cytokine metabolic process, regulation of cell proliferation, regulation of phosphorylation, regulation of apoptosis, regulation of programmed cell death, positive regulation of catalytic activity, positive regulation of caspase activity, regulation o

• Subcellular Location：
• Membrane ; Single-pass type II membrane protein .; [Tumor necrosis factor ligand superfamily member 15, secreted form]: Secreted.

• Expression：
• Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.

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