• Gene Name：
• CDH3

• Protein Name：
• Cadherin-3

• Human Gene Id：
• 1001

• Human Swiss Prot No：
• P22223

• Mouse Swiss Prot No：
• P10287

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• CDH3;CDHP;Cadherin-3;Placental cadherin;P-cadherin

• Detection Method：
• Colorimetric

• Background：
• disease:Defects in CDH3 are the cause of ectodermal dysplasia with ectrodactyly and macular dystrophy (EEM) [MIM:225280]; also known as EEM syndrome, Albrectsen-Svendsen syndrome or Ohdo-Hirayama-Terawaki syndrome. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EEM is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly.,disease:Defects in CDH3 are the cause of hypotrichosis with juvenile macular dystrophy (HJMD) [MIM:601553]. HJMD is a rare autosomal recessive disorder characterized by early hair loss heralding severe degenerative changes of the retinal macula and culminating in blindness during the second to third decade of life.,function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,online information:Retina International's Scientific Newsletter,similarity:Contains 5 cadherin domains.,subunit:Interacts with CDCP1.,tissue specificity:Expressed in some normal epithelial tissues and in some carcinoma cell lines.,

• Function：
• cell adhesion, homophilic cell adhesion, sensory perception, visual perception, response to wounding, cell-cell adhesion, biological adhesion, wound healing, response to drug, neurological system process, cognition, sensory perception of light stimulus,

• Subcellular Location：
• Cell membrane; Single-pass type I membrane protein.

• Expression：
• Expressed in some normal epithelial tissues and in some carcinoma cell lines.

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