• Target：
• GGT4 HC

• Fields：
• >>Taurine and hypotaurine metabolism;>>Glutathione metabolism;>>Metabolic pathways

• Gene Name：
• GGT7

• Protein Name：
• Gamma-glutamyltransferase 7

• Human Gene Id：
• 2686

• Human Swiss Prot No：
• Q9UJ14

• Mouse Gene Id：
• 207182

• Mouse Swiss Prot No：
• Q99JP7

• Rat Gene Id：
• 156275

• Rat Swiss Prot No：
• Q99MZ4

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human Gamma-glutamyltransferase 4. AA range:423-472

• Specificity：
• Cleaved-GGT4 HC (T472) Polyclonal Antibody detects endogenous levels of fragment of activated GGT4 HC protein resulting from cleavage adjacent to T472.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GGT7;GGTL3;GGTL5;Gamma-glutamyltransferase 7;GGT 7;Gamma-glutamyltransferase-like 3;Gamma-glutamyltransferase-like 5;Gamma-glutamyltranspeptidase 7;Glutathione hydrolase 7

• Observed Band(KD)：
• 50kD

• Background：
• This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.,function:Cleaves glutathione conjugates.,pathway:Sulfur metabolism; glutathione metabolism.,similarity:Belongs to the gamma-glutamyltransferase family.,subunit:Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity). Isoform 3 interacts with FAM57A.,tissue specificity:Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.,

• Subcellular Location：
• Membrane ; Single-pass type II membrane protein .

• Expression：
• Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.

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