ITGAE (heavy chain, Cleaved-Ala179) rabbit pAb

    • Catalog No.:YC0172
    • Applications:WB;IHC
    • Reactivity:Human;Rat;Mouse;
      • Target:
      • ITGAE
      • Fields:
      • >>Regulation of actin cytoskeleton
      • Gene Name:
      • ITGAE
      • Protein Name:
      • ITGAE (heavy chain, Cleaved-Ala179)
      • Human Gene Id:
      • 3682
      • Human Swiss Prot No:
      • P38570
      • Mouse Swiss Prot No:
      • Q60677
      • Immunogen:
      • Synthesized peptide derived from human ITGAE (heavy chain, Cleaved-Ala179)
      • Specificity:
      • This antibody detects endogenous levels of Human ITGAE (heavy chain, Cleaved-Ala179, protein was cleaved amino acid sequence between 178-179 )
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500-2000;IHC-p 1:50-300
      • Purification:
      • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • Integrin alpha-E (HML-1 antigen;Integrin alpha-IEL;Mucosal lymphocyte 1 antigen;CD antigen CD103) [Cleaved into: Integrin alpha-E light chain;Integrin alpha-E heavy chain]
      • Observed Band(KD):
      • 110 128kD
      • Background:
      • integrin subunit alpha E(ITGAE) Homo sapiens Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008],
      • Function:
      • domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.,induction:Integrin alpha-E/beta-7 is induced by TGFB1.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 5 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.,tissue specificity:Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.,
      • Subcellular Location:
      • Membrane; Single-pass type I membrane protein.
      • Expression:
      • Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.
      • Products Images
      • Immunohistochemical analysis of paraffin-embedded human uterus. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).