• Target：
• MMP-8

• Gene Name：
• MMP8 CLG1

• Protein Name：
• MMP8 (Cleaved-Leu101)

• Human Gene Id：
• 4317

• Human Swiss Prot No：
• P22894

• Mouse Gene Id：
• 17394

• Mouse Swiss Prot No：
• O70138

• Rat Gene Id：
• 63849

• Rat Swiss Prot No：
• O88766

• Immunogen：
• Synthesized peptide derived from human MMP8 (Cleaved-Leu101)

• Specificity：
• This antibody detects endogenous levels of Human,Mouse,Rat MMP8 (Cleaved-Leu101, protein was cleaved amino acid sequence between 100-101 )

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Neutrophil collagenase (EC 3.4.24.34;Matrix metalloproteinase-8;MMP-8;PMNL collagenase;PMNL-CL)

• Observed Band(KD)：
• 40 53kD

• Background：
• catalytic activity:Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 3 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Cannot be activated without removal of the activation peptide.,function:Can degrade fibrillar type I, II, and III collagens.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,subcellular location:Stored in intracellular granules.,tissue specificity:Neutrophils.,

• Function：
• skeletal system development, ossification, proteolysis, collagen catabolic process, collagen metabolic process,multicellular organismal metabolic process, multicellular organismal catabolic process, multicellular organismal macromolecule metabolic process, bone development,

• Subcellular Location：
• Cytoplasmic granule. Secreted, extracellular space, extracellular matrix . Stored in intracellular granules.

• Expression：
• Neutrophils.

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