- Home
- About
- Promotions
-
Products
-
Elisa Kits
- |
-
Primary antibodies
- |
-
Secondary antibodies
- |
-
Proteins
- |
-
IHC reagents
- |
-
WB reagents
- PonceauS Staining Solution
- PBST Washing Buffer, 10X
- 1.5M Tris-HCl Buffer, pH8.8
- 1M Tris-HCl Buffer, pH6.8
- 10% SDS Solution
- Prestained Protein Marker
- TBST Washing Buffer, 10X
- SDS PAGE Loading Buffer, 5X
- Stripping Buffered Solution
- Tris Buffer, pH7.4, 10X
- Total Protein Extraction Kit
- Running Buffer, 10X
- Transfer Buffer, 10X
- 30% Acr-Bis(29:1) Solution
- Tris电泳液速溶颗粒
- PBS(1X, premixed powder)
- TBS(1X, premixed powder)
- 快速封闭液
- 转膜液速溶颗粒
- Chemical reagents
- News
- Distributor
- Resources
- Contact
- Home
- >
- Info
- >
- Akt1 protein
- >
- Go Back
Akt1 protein
- Catalog No.：YD0071
- Applications：WB;SDS-PAGE
- Reactivity：Human
- Protein Name：
- Akt1 protein
- Sequence：
- Amino acid: 13-253, with his-MBP tag.
- Formulation：
- Liquid in PBS
- Concentration：
- SDS-PAGE >90%
- Storage Stability：
- -20°C/6 mouth,-80°C for long storage
- Other Name：
- RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
- Function：
- protein import into nucleus, translocation, regulation of cyclin-dependent protein kinase activity, G1/S transition of mitotic cell cycle, polysaccharide biosynthetic process, mitotic cell cycle, regulation of cell growth, blood vessel development, leukocyte homeostasis, placenta development, hair follicle development, vasculature development,regulation of sodium ion transport, lymphocyte homeostasis, reproductive developmental process, polysaccharide metabolic process, glycogen metabolic process, glycogen biosynthetic process, regulation of glycogen biosynthetic process, monosaccharide metabolic process, glucose metabolic process, cellular glucan metabolic process, generation of precursor metabolites and energy, regulation of carbohydrate metabolic process, energy reserve metabolic process,regulation of translation, protein amino acid phosphorylation, negative regulation of protein kina
- Subcellular Location：
- Cytoplasm . Nucleus . Cell membrane . Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529). .
- Expression：
- Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages.
