• Target：
• ANP32A

• Gene Name：
• ANP32A

• Protein Name：
• Acidic leucine-rich nuclear phosphoprotein 32 family member A

• Human Gene Id：
• 8125

• Human Swiss Prot No：
• P39687

• Mouse Swiss Prot No：
• O35381

• Immunogen：
• Purified recombinant fragment of human ANP32A expressed in E. Coli.

• Specificity：
• ANP32A Monoclonal Antibody detects endogenous levels of ANP32A protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ANP32A;C15orf1;LANP;MAPM;PHAP1;Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic nuclear phosphoprotein pp32;Leucine-rich acidic nuclear protein;LANP;Mapmodulin;Potent heat-stable protein phosphatase 2A inhibito

• Molecular Weight(Da)：
• 29kD

• References：
• 1. Genome Res. 2004 Oct;14(10B):2121-7.
  2. Cell. 2005 Sep 23;122(6):957-68.
  3. Cell. 2006 May 19;125(4):801-14.

• Background：
• function:Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.,PTM:Phosphorylated on serine residues.,PTM:The N-terminus is blocked.,similarity:Belongs to the ANP32 family.,similarity:Contains 4 LRR (leucine-rich) repeats.,subcellular location:Shuttles between nucleus and cytoplasm.,subunit:Component of the SET complex, which also contains SET, APEX1, HMGB2 and NME1. Directly interacts with SET. Interacts with ATXN1/SCA1. Interacts with MAP1B (By similarity). Interacts with ELAVL1. Part of the INHAT (inhibitor of histone acetyltransferases) complex. Interacts with E4F1.,tissue specificity:Expressed in all tissues tested. Highly expressed in kidney and skeletal muscle, moderate levels of expression in brain, placenta and pancreas, and weakly expressed in lung. Found in all regions of the brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in amygdala.,

• Function：
• function:Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.,PTM:Phosphorylated on serine residues.,PTM:The N-terminus is blocked.,similarity:Belongs to the ANP32 family.,similarity:Contains 4 LRR (leucine-rich) repeats.,subcellular location:Shuttles between nucleus and cytoplasm.,subunit:Component of the SET complex, which also contains SET, APEX1, HMGB2 and NME1. Directly interacts with SET. Interacts with ATXN1/SCA1. Interacts with MAP1B (By similarity). Interacts with ELAVL1

• Subcellular Location：
• Nucleus . Cytoplasm . Endoplasmic reticulum. Translocates to the cytoplasm during the process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm. .

• Expression：
• Expressed in all tissues tested. Highly expressed in kidney and skeletal muscle, moderate levels of expression in brain, placenta and pancreas, and weakly expressed in lung. Found in all regions of the brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in amygdala.

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