• Target：
• Arg

• Fields：
• >>ErbB signaling pathway;>>Ras signaling pathway;>>Chemical carcinogenesis - reactive oxygen species;>>Viral myocarditis

• Gene Name：
• ABL2

• Protein Name：
• Tyrosine-protein kinase ABL2

• Human Gene Id：
• 27

• Human Swiss Prot No：
• P42684

• Mouse Swiss Prot No：
• Q4JIM5

• Immunogen：
• Purified recombinant fragment of Arg expressed in E. Coli.

• Specificity：
• Arg Monoclonal Antibody detects endogenous levels of Arg protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ABL2;ABLL;ARG;Abelson tyrosine-protein kinase 2;Abelson murine leukemia viral oncogene homolog 2;Abelson-related gene protein;Tyrosine-protein kinase ARG

• Molecular Weight(Da)：
• 128kD

• References：
• 1. Yoshimi I, Takashi I, Tsuneyuki O, et al. Blood. 2000; 95(6): 2126-2131.
  2. Scheijen, B. and Griffin, J.D. Oncogene. 2002); 21:3314-33.

• Background：
• This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009],

• Function：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Magnesium or manganese.,enzyme regulation:Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the amino-terminal cap, and contributions from an amino-terminal myristoyl group and phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid leukemia (CML).,function:Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosph

• Subcellular Location：
• Cytoplasm, cytoskeleton.

• Expression：
• Widely expressed.

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