• Target：
• BDH1

• Fields：
• >>Butanoate metabolism;>>Metabolic pathways

• Gene Name：
• BDH1

• Protein Name：
• D-beta-hydroxybutyrate dehydrogenase, mitochondrial

• Human Gene Id：
• 622

• Human Swiss Prot No：
• Q02338

• Mouse Gene Id：
• 71911

• Mouse Swiss Prot No：
• Q80XN0

• Immunogen：
• Purified recombinant fragment of human BDH1 expressed in E. Coli.

• Specificity：
• BDH1 Monoclonal Antibody detects endogenous levels of BDH1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• BDH1;BDH;D-beta-hydroxybutyrate dehydrogenase; mitochondrial;BDH;3-hydroxybutyrate dehydrogenase

• Molecular Weight(Da)：
• 38kD

• References：
• 1. Biochemistry. 1996 Jun 25;35(25):8158-65.
  2. Biochemistry. 2000 Oct 3;39(39):11928-38.
  3. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15089-94.

• Background：
• This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH.,enzyme regulation:Requires phosphatidylcholine as an allosteric activator for enzymatic activity.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,subunit:Homotetramer.,

• Subcellular Location：
• Mitochondrion inner membrane . Mitochondrion matrix .

• Expression：
• Heart,Lung,Ovary,

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