• Target：
• BHMT

• Fields：
• >>Glycine, serine and threonine metabolism;>>Cysteine and methionine metabolism;>>Metabolic pathways

• Gene Name：
• BHMT

• Protein Name：
• Betaine--homocysteine S-methyltransferase 1

• Human Gene Id：
• 635

• Human Swiss Prot No：
• Q93088

• Mouse Swiss Prot No：
• O35490

• Immunogen：
• Purified recombinant fragment of BHMT expressed in E. Coli.

• Specificity：
• BHMT Monoclonal Antibody detects endogenous levels of BHMT protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• BHMT;Betaine--homocysteine S-methyltransferase 1

• Molecular Weight(Da)：
• 45kD

• References：
• 1. Genome Res. 2004 Oct;14(10B):2121-7.
  2. Biochem J. 2007 Jan 1;401(1):87-96.

• Background：
• betaine--homocysteine S-methyltransferase(BHMT) Homo sapiens This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:Trimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine.,cofactor:Binds 1 zinc ion per subunit.,function:Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.,pathway:Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2.,pathway:Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.,similarity:Contains 1 Hcy-binding domain.,subunit:Homotetramer.,tissue specificity:Found exclusively in liver and kidney.,

• Subcellular Location：
• Cytoplasm, cytosol . Nucleus . Predominantly localized in the cytoplasm with a small fraction detected in the nucleus. Translocates into the nucleus upon oxidative stress. .

• Expression：
• Found exclusively in liver and kidney.

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