• Target：
• CD86

• Fields：
• >>Cell adhesion molecules;>>Toll-like receptor signaling pathway;>>Intestinal immune network for IgA production;>>Type I diabetes mellitus;>>Kaposi sarcoma-associated herpesvirus infection;>>Transcriptional misregulation in cancer;>>Autoimmune thyroid disease;>>Systemic lupus erythematosus;>>Rheumatoid arthritis;>>Allograft rejection;>>Graft-versus-host disease;>>Viral myocarditis

• Gene Name：
• CD86

• Protein Name：
• T-lymphocyte activation antigen CD86

• Human Gene Id：
• 942

• Human Swiss Prot No：
• P42081

• Mouse Swiss Prot No：
• P42082

• Immunogen：
• Purified recombinant fragment of human CD86 expressed in E. Coli.

• Specificity：
• CD86 Monoclonal Antibody detects endogenous levels of CD86 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CD86;CD28LG2;T-lymphocyte activation antigen CD86;Activation B7-2 antigen;B70;BU63;CTLA-4 counter-receptor B7.2;FUN-1;CD antigen CD86

• Molecular Weight(Da)：
• 60-80kD

• References：
• 1. Clin Exp Allergy. 2009 Dec;39(12):1852-6.
  2. Am J Hum Genet. 2009 Nov;85(5):628-42.
  3. Immunology. 2009 Nov;128(3):334-41

• Background：
• This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011],

• Function：
• function:Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.,online information:CD86 entry,PTM:Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with adenovirus subgroup B fiber proteins and acts as

• Subcellular Location：
• Cell membrane; Single-pass type I membrane protein.

• Expression：
• Expressed by activated B-lymphocytes and monocytes.

Ciprofloxacin promotes polarization of CD86+CD206‑ macrophages to suppress liver cancer. ONCOLOGY REPORTS Oncol Rep. 2020 Jul;44(1):91-102 WB Human 1:1000 HepG2 cell

Fan, Mengtian, et al. "Ciprofloxacin promotes polarization of CD86+ CD206‑macrophages to suppress liver cancer." Oncology reports 44.1 (2020): 91-102.

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