• Target：
• CDC25C

• Fields：
• >>Cell cycle;>>Oocyte meiosis;>>Progesterone-mediated oocyte maturation;>>Human immunodeficiency virus 1 infection;>>MicroRNAs in cancer

• Gene Name：
• CDC25C

• Protein Name：
• M-phase inducer phosphatase 3

• Human Gene Id：
• 995

• Human Swiss Prot No：
• P30307

• Mouse Swiss Prot No：
• P48967

• Immunogen：
• Purified recombinant fragment of human CDC25C expressed in E. Coli.

• Specificity：
• CDC25C Monoclonal Antibody detects endogenous levels of CDC25C protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CDC25C;M-phase inducer phosphatase 3;Dual specificity phosphatase Cdc25C

• Molecular Weight(Da)：
• 53kD

• References：
• 1. Cancer Cell. 2007 Mar;11(3):275-89.
  2. Int J Biochem Cell Biol. 2007;39(9):1707-13.
  3. Int J Cancer. 2010 May 1;126(9):2199-210.

• Background：
• cell division cycle 25C(CDC25C) Homo sapiens This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015],

• Function：
• catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,developmental stage:Expressed predominantly in G2 phase.,function:Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity.,PTM:Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase.,similarity:Belongs to the MPI phosphatase family.,similarity:Contains 1 rhodanese domain.,subunit:Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity.,

• Subcellular Location：
• Nucleus .

• Expression：
• Colon carcinoma,Epithelium,Skin,Testis,

Elevated TAB182 enhances the radioresistance of esophageal squamous cell carcinoma through G2-M checkpoint modulation. Cancer Medicine Cancer Med-Us. 2021 May;10(9):3101-3112 WB Human TE-1 cell， TE-10 cell

ERβ-activated LINC01018 promotes endometriosis development by regulating the CDC25C/CDK1/CyclinB1 pathway Journal of Genetics and Genomics Ruihui Lu WB Human 1:1000 ectopic endometrial stromal cells (ECSCs)

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