• Target：
• Dynamin I

• Fields：
• >>Phospholipase D signaling pathway;>>Endocytosis;>>Synaptic vesicle cycle;>>Endocrine and other factor-regulated calcium reabsorption;>>Bacterial invasion of epithelial cells

• Gene Name：
• DNM1

• Protein Name：
• Dynamin-1

• Human Gene Id：
• 1759

• Human Swiss Prot No：
• Q05193

• Mouse Swiss Prot No：
• P39053

• Immunogen：
• Purified recombinant fragment of human Dynamin I expressed in E. Coli.

• Specificity：
• Dynamin I Monoclonal Antibody detects endogenous levels of Dynamin I protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• DNM1;DNM;Dynamin-1

• Molecular Weight(Da)：
• 97kD

• References：
• 1. Annie Quan and Phillip J. Robinson. Methods Enzymol. 2005; 404:556-69.
  2. Jiyun Yoo, Moon-Jin Jeong, Byoung-Mog Kwon. J. Biol. Chem., Mar 2002; 277: 11904 – 11909

• Background：
• dynamin 1(DNM1) Homo sapiens This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:GTP + H(2)O = GDP + phosphate.,function:Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.,similarity:Belongs to the dynamin family.,similarity:Contains 1 GED domain.,similarity:Contains 1 PH domain.,subcellular location:Microtubule-associated.,subunit:Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3.,

• Subcellular Location：
• Cytoplasm . Cytoplasm, cytoskeleton . Microtubule-associated.

• Expression：
• Brain,Platelet,PNS,

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