EphA3 Monoclonal Antibody

    • Catalog No.：YM0223
    • Applications：WB;ELISA
    • Reactivity：Human
      • Target：
      • EphA3
      • Fields：
      • >>Axon guidance
      • Gene Name：
      • EPHA4
      • Protein Name：
      • Ephrin type-A receptor 4
      • Human Gene Id：
      • 2043
      • Human Swiss Prot No：
      • P54764
      • Mouse Swiss Prot No：
      • Q03137
      • Immunogen：
      • Purified recombinant fragment of EphA3 (aa751-983) expressed in E. Coli.
      • Specificity：
      • EphA3 Monoclonal Antibody detects endogenous levels of EphA3 protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
      • Purification：
      • Affinity purification
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • EPHA4;HEK8;SEK;TYRO1;Ephrin type-A receptor 4;EPH-like kinase 8;EK8;hEK8;Tyrosine-protein kinase TYRO1;Tyrosine-protein kinase receptor SEK
      • Molecular Weight(Da)：
      • 110kD
      • References：
      • 1. Nat Genet. 2004 Jan;36(1):40-5.
        2. Cell. 2005 Oct 21;123(2):291-304.
      • Background：
      • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015],
      • Function：
      • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:The protein kinase domain mediates interaction with NGEF/ephexin-1.,function:Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in a signal transduction process involved in hindbrain pattern formation.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with the src family kinase, p59-Fyn, through the major phosphorylation site at position Tyr-602. Interacts with NGEF/ephexin-1.,tissue specificity:Ubiquitous.
      • Subcellular Location：
      • Cell membrane ; Single-pass type I membrane protein . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse, postsynaptic density membrane . Early endosome . Cell junction, adherens junction . Clustered upon activation and targeted to early endosome. .
      • Expression：
      • Ubiquitous.
      • Products Images
      • Western Blot analysis using EphA3 Monoclonal Antibody against truncated Trx-EphA3 recombinant protein (1) and truncated EphA3(aa566-983)-hIgGFc transfected CHO-K1 cell lysate(2).

      Attributes

      • Code：
      • YM0223
      • Size
      • 50μL / 100μL / 200μL
      • Price$：
      • 210 / 350 / 600
      • Delivery：
      • 2024-05-11
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