• Target：
• EphB1

• Fields：
• >>Axon guidance

• Gene Name：
• EPHB1

• Protein Name：
• Ephrin type-B receptor 1

• Human Gene Id：
• 2047

• Human Swiss Prot No：
• P54762

• Mouse Swiss Prot No：
• Q8CBF3

• Immunogen：
• Purified recombinant fragment of EphB1 (aa19-133) expressed in E. Coli.

• Specificity：
• EphB1 Monoclonal Antibody detects endogenous levels of EphB1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• EPHB1;ELK;EPHT2;HEK6;NET;Ephrin type-B receptor 1;ELK;EPH tyrosine kinase 2;EPH-like kinase 6;EK6;hEK6;Neuronally-expressed EPH-related tyrosine kinase;NET;Tyrosine-protein kinase receptor EPH-2

• Molecular Weight(Da)：
• 110kD

• References：
• 1. J Cell Sci. 2002 Aug 1;115(Pt 15):3073-81.
  2. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9219-24.

• Background：
• Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-B family. Binds to ephrin-B1, -B2 and -B3. May be involved in cell-cell interactions in the nervous system.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:The ligand-activated form interacts with GRB2, GRB10 and NCK through their respective SH2 domains. The GRB10 SH2 domain binds EPHB1 through Tyr-928, while GRB2 binds residues within the catalytic domain. Interacts with EPHB6. The NCK SH2 domain binds EPHB1 through Tyr-594. Interacts with PRKCABP.,tissue specificity:Preferentially expressed in brain.,

• Subcellular Location：
• Cell membrane ; Single-pass type I membrane protein . Early endosome membrane . Cell projection, dendrite .

• Expression：
• Preferentially expressed in brain.

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