• Target：
• Fucokinase

• Fields：
• >>Fructose and mannose metabolism;>>Amino sugar and nucleotide sugar metabolism;>>Metabolic pathways;>>Biosynthesis of nucleotide sugars

• Gene Name：
• FUK

• Protein Name：
• L-fucose kinase

• Human Gene Id：
• 197258

• Human Swiss Prot No：
• Q8N0W3

• Immunogen：
• Purified recombinant fragment of human Fucokinase expressed in E. Coli.

• Specificity：
• Fucokinase Monoclonal Antibody detects endogenous levels of Fucokinase protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• FUK;L-fucose kinase;Fucokinase

• Molecular Weight(Da)：
• 118kD

• References：
• 1. J Hum Ergol (Tokyo). 2009 Dec;38(2):81-8.
  2. Ophthalmologica. 2009;223(4):233-8.

• Background：
• fucokinase(FUK) Homo sapiens The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:ATP + L-fucose = ADP + beta-L-fucose 1-phosphate.,function:Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.,similarity:Belongs to the GHMP kinase family.,

• Subcellular Location：
• cytoplasm,cytosol,

• Expression：
• Expressed in fibroblasts.

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