• Target：
• HAS1

• Gene Name：
• HAS1

• Protein Name：
• Hyaluronan synthase 1

• Human Gene Id：
• 3036

• Human Swiss Prot No：
• Q8IYH3

• Immunogen：
• Purified recombinant fragment of human HAS1 expressed in E. Coli.

• Specificity：
• HAS1 Monoclonal Antibody detects endogenous levels of HAS1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 65kD

• References：
• 1. Clin Lymphoma. 2005 Mar;5(4):253-6.
  2. Mol Cell Biochem. 2006 Nov;292(1-2):169-78.
  3. J Biol Chem. 2008 Jun 13;283(24):16781-9.

• Background：
• Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheuma

• Function：
• catalytic activity:UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan).,catalytic activity:UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan).,cofactor:Magnesium.,function:Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate.,online information:GlycoGene database,pathway:Glycan biosynthesis; hyaluronan biosynthesis.,similarity:Belongs to the nodC/HAS family.,tissue specificity:Highly expressed in ovary followed by spleen, thymus,

• Subcellular Location：
• cytoplasm,plasma membrane,integral component of plasma membrane,integral component of membrane,

• Expression：
• Fetal brain,Lymph node,Ovary,

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