• Target：
• IL-2

• Fields：
• >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>PI3K-Akt signaling pathway;>>C-type lectin receptor signaling pathway;>>JAK-STAT signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>T cell receptor signaling pathway;>>Intestinal immune network for IgA production;>>Type I diabetes mellitus;>>Yersinia infection;>>Chagas disease;>>Measles;>>Human T-cell leukemia virus 1 infection;>>Coronavirus disease - COVID-19;>>Pathways in cancer;>>Autoimmune thyroid disease;>>Inflammatory bowel disease;>>Allograft rejection;>>Graft-versus-host disease

• Gene Name：
• IL2

• Protein Name：
• Interleukin-2

• Human Gene Id：
• 3558

• Human Swiss Prot No：
• P60568

• Mouse Swiss Prot No：
• P04351

• Immunogen：
• Purified recombinant fragment of IL-2 expressed in E. Coli.

• Specificity：
• IL-2 Monoclonal Antibody detects endogenous levels of IL-2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• IL2;Interleukin-2;IL-2;T-cell growth factor;TCGF;Aldesleukin

• Molecular Weight(Da)：
• 18kD

• References：
• 1. Leukemia. 2008 Dec;22(12):2201-7.
  2. J Immunol. 2008 Feb 1;180(3):1490-8.

• Background：
• The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008],

• Function：
• disease:A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.,function:Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.,online information:Interleukin-2 entry,online information:The Singapore human mutation and polymorphism database,pharmaceutical:Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.,similarity:Belongs to the IL-2 family.,

• Subcellular Location：
• Secreted.

• Expression：
• Blood,PCR rescued clones,Placenta,Spleen,

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