Lyn Monoclonal Antibody

    • Catalog No.：YM0424
    • Applications：WB;ELISA
    • Reactivity：Human
      • Target：
      • Lyn
      • Fields：
      • >>Chemokine signaling pathway;>>NF-kappa B signaling pathway;>>Platelet activation;>>B cell receptor signaling pathway;>>Fc epsilon RI signaling pathway;>>Fc gamma R-mediated phagocytosis;>>Long-term depression;>>Epithelial cell signaling in Helicobacter pylori infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Epstein-Barr virus infection;>>Viral carcinogenesis;>>Lipid and atherosclerosis
      • Gene Name：
      • LYN
      • Protein Name：
      • Tyrosine-protein kinase Lyn
      • Human Gene Id：
      • 4067
      • Human Swiss Prot No：
      • P07948
      • Mouse Swiss Prot No：
      • P25911
      • Immunogen：
      • Purified recombinant fragment of Lyn expressed in E. Coli.
      • Specificity：
      • Lyn Monoclonal Antibody detects endogenous levels of Lyn protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
      • Purification：
      • Affinity purification
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • LYN;JTK8;Tyrosine-protein kinase Lyn;Lck/Yes-related novel protein tyrosine kinase;V-yes-1 Yamaguchi sarcoma viral related oncogene homolog;p53Lyn;p56Lyn
      • Molecular Weight(Da)：
      • 59kD
      • References：
      • 1. Sakaguchi, A.Y.,et al.Genet. 34: 175.
        2. Hibbs, M.L.,et al.Biol. 29: 397-400.
        3. Williams, J.C.,et al.Trends Biochem. Sci. 23: 179-184.
      • Background：
      • This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],
      • Function：
      • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with phosphorylated LIME1 and with CD79A upon BCR activation. Interacts with Epstein-Barr virus LMP2A. Interacts with TGFB1I1. Interaction, via the SH2 and SH3, domains with MUC1 is stimulated by IL7 and, the subsequent phosphorylation increases the binding between MUC1 and CTNNB1/beta-catenin. Interacts with PPP1R15A via the SH3 domain.,tissue specificity:Expressed in primary neuroblastoma tumors.,
      • Subcellular Location：
      • Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Membrane ; Lipid-anchor . Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. Detected on plasma membrane lipid rafts.
      • Expression：
      • Detected in monocytes (at protein level). Detected in placenta, and in fetal brain, lung, liver and kidney. Widely expressed in a variety of organs, tissues, and cell types such as epidermoid, hematopoietic, and neuronal cells. Expressed in primary neuroblastoma tumors.
      • Products Images
      • Western Blot analysis using Lyn Monoclonal Antibody agains HL60 (1), L540 (2), SLLP-M2 (3), SEM (4) and Ramos (5) cell lysate.

      Attributes

      • Code：
      • YM0424
      • Size
      • 50μL / 100μL / 200μL
      • Price$：
      • 210 / 350 / 600
      • Delivery：
      • 2024-12-29
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