• Target：
• M-CSF

• Fields：
• >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>PI3K-Akt signaling pathway;>>Osteoclast differentiation;>>Hematopoietic cell lineage;>>TNF signaling pathway;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Rheumatoid arthritis

• Gene Name：
• CSF1

• Protein Name：
• Macrophage colony-stimulating factor 1

• Human Gene Id：
• 1435

• Human Swiss Prot No：
• P09603

• Mouse Swiss Prot No：
• P07141

• Immunogen：
• Purified recombinant fragment of human M-CSF expressed in E. Coli.

• Specificity：
• M-CSF Monoclonal Antibody detects endogenous levels of M-CSF protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CSF1;Macrophage colony-stimulating factor 1;CSF-1;M-CSF;MCSF;Lanimostim

• Molecular Weight(Da)：
• 60kD

• References：
• 1. J Biol Chem. 1992 Feb 5;267(4):2190-9.
  2. FEBS Lett. 1987 Oct 5;222(2):341-4.
  3. Mol Reprod Dev. 1997 Jan;46(1):4-10.

• Background：
• The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011],

• Function：
• function:Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.,PTM:Glycosylation and proteolytic cleavage yield different soluble forms. A high molecular weight soluble form is a proteoglycan containing chondroitin sulfate.,PTM:Isoform 1 is N- and O-glycosylated. Isoform 3 is N-glycosylated.,subunit:Homodimer or heterodimer; disulfide-linked.,

• Subcellular Location：
• Cell membrane ; Single-pass type I membrane protein .; [Processed macrophage colony-stimulating factor 1]: Secreted, extracellular space.

• Expression：
• Endometrium,Kidney,Pancreatic carcinoma,T lymphoblast,Trophoblast,Urine,

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