• Target：
• N-cadherin

• Fields：
• >>Cell adhesion molecules;>>Arrhythmogenic right ventricular cardiomyopathy

• Gene Name：
• CDH2

• Protein Name：
• Cadherin-2

• Human Gene Id：
• 1000

• Human Swiss Prot No：
• P19022

• Mouse Gene Id：
• 12558

• Mouse Swiss Prot No：
• P15116

• Rat Gene Id：
• 83501

• Rat Swiss Prot No：
• Q9Z1Y3

• Immunogen：
• Purified recombinant fragment of human N-cadherin expressed in E. Coli.

• Specificity：
• N-cadherin Monoclonal Antibody detects endogenous levels of N-cadherin protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CDH2;CDHN;NCAD;Cadherin-2;CDw325;Neural cadherin;N-cadherin;CD antigen CD325

• References：
• 1. J Biol Chem. 2007 Mar 16;282(11):8545-56.
  2. Mol Cell Biochem. 2007 Aug;302(1-2):19-26.
  3. Urol Oncol. 2010 Mar-Apr;28(2):180-8.

• Background：
• This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015],

• Function：
• function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism.,similarity:Contains 5 cadherin domains.,subunit:Interacts with CDCP1.,

• Subcellular Location：
• Cell membrane ; Single-pass type I membrane protein . Cell membrane, sarcolemma . Cell junction . Cell surface . Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and at sarcolemma in cardiomyocytes. .

• Expression：
• Brain,Epithelium,Liver,

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