• Target：
• Pax-8

• Fields：
• >>Thyroid hormone synthesis;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Thyroid cancer

• Gene Name：
• PAX8

• Protein Name：
• Paired box protein Pax-8

• Human Gene Id：
• 7846

• Human Swiss Prot No：
• Q06710

• Mouse Swiss Prot No：
• Q00288

• Immunogen：
• Purified recombinant fragment of human Pax-8 expressed in E. Coli.

• Specificity：
• Pax-8 Monoclonal Antibody detects endogenous levels of Pax-8 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PAX8;Paired box protein Pax-8

• Molecular Weight(Da)：
• 48kD

• References：
• 1. Thyroid. 2009 Jan;19(1):61-8.
  2. Cancer Genet Cytogenet. 2010 Jan 1;196(1):7-13.
  3. Cancer Cytopathol. 2010 Oct 25;118(5):298-302.

• Background：
• This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010],

• Function：
• caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,developmental stage:In developing excretory system, during thyroid differentiation and in adult thyroid.,disease:Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) [MIM:218700]. CHNG2 is a disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.,function:Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cell

• Subcellular Location：
• Nucleus.

• Expression：
• Expressed in the excretory system, thyroid gland and Wilms tumors.

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