• Target：
• Rab 10

• Fields：
• >>Endocytosis;>>AMPK signaling pathway

• Gene Name：
• RAB10

• Protein Name：
• Ras-related protein Rab-10

• Human Gene Id：
• 10890

• Human Swiss Prot No：
• P61026

• Mouse Gene Id：
• 19325

• Mouse Swiss Prot No：
• P61027

• Immunogen：
• Purified recombinant fragment of human Rab 10 expressed in E. Coli.

• Specificity：
• Rab 10 Monoclonal Antibody detects endogenous levels of Rab 10 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• RAB10;Ras-related protein Rab-10

• Molecular Weight(Da)：
• 23kD

• References：
• 1. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6508-12.
  2. J Biol Chem. 2003 Apr 25;278(17):15373-80.
  3. Mol Med. 2010 Jul-Aug;16(7-8):247-53.

• Background：
• RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009],

• Function：
• function:May be involved in vesicular trafficking and neurotransmitter release.,similarity:Belongs to the small GTPase superfamily. Rab family.,

• Subcellular Location：
• Cytoplasmic vesicle membrane ; Lipid-anchor ; Cytoplasmic side . Golgi apparatus membrane . Golgi apparatus, trans-Golgi network membrane . Endosome membrane . Recycling endosome membrane . Cytoplasmic vesicle, phagosome membrane . Cytoplasm, cytoskeleton, cilium basal body . Endoplasmic reticulum membrane . Cytoplasm, perinuclear region . Associates with SLC2A4/GLUT4 storage vesicles (PubMed:22908308). Localizes to the base of the cilium when phosphorylated by LRRK2 on Thr-73 (PubMed:20576682, PubMed:30398148). Transiently associates with phagosomes (By similarity). Localizes to the endoplasmic reticulum at domains of new tubule growth (PubMed:23263280). .

• Expression：
• Expressed in the hippocampus (PubMed:29562525). Expressed in neutrophils (at protein level) (PubMed:29127255). Expressed in the testis (at protein level) (PubMed:28067790).

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