ROR1 Monoclonal Antibody

    • Catalog No.：YM0563
    • Applications：WB;IF;ELISA
    • Reactivity：Human
      • Target：
      • ROR1
      • Fields：
      • >>Wnt signaling pathway
      • Gene Name：
      • ROR1
      • Protein Name：
      • Tyrosine-protein kinase transmembrane receptor ROR1
      • Human Gene Id：
      • 4919
      • Human Swiss Prot No：
      • Q01973
      • Mouse Swiss Prot No：
      • Q9Z139
      • Immunogen：
      • Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells
      • Specificity：
      • ROR1 Monoclonal Antibody detects endogenous levels of ROR1 protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
      • Purification：
      • Affinity purification
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • ROR1;NTRKR1;Tyrosine-protein kinase transmembrane receptor ROR1;Neurotrophic tyrosine kinase; receptor-related 1
      • Molecular Weight(Da)：
      • 104kD
      • References：
      • 1. J Cell Sci. 2005 Jan 15;118(Pt 2):433-46.
        2. Oncogene. 1996 Oct 3;13(7):1555-9.
      • Background：
      • This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012],
      • Function：
      • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,developmental stage:Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.,function:Tyrosine-protein kinase receptor whose role is not yet clear.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 kringle domain.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed strongly in human heart, lung, and kidney, but weakly in the CNS. The short isoform is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.,
      • Subcellular Location：
      • Membrane ; Single-pass type I membrane protein. Cell projection, axon .
      • Expression：
      • Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.
      • Products Images
      • Western Blot analysis using ROR1 Monoclonal Antibody against extracellular domain of human ROR1 (aa30-423).
      • Confocal immunofluorescence analysis of HEK293 cells trasfected with extracellular ROR1 (aa30-406)-hIgGFc using ROR1 Monoclonal Antibody (green). Blue: DRAQ5 fluorescent DNA dye.

      Attributes

      • Code：
      • YM0563
      • Size
      • 50μL / 100μL / 200μL
      • Price$：
      • 210 / 350 / 600
      • Delivery：
      • 2024-05-06
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