• Target：
• TBX5

• Gene Name：
• TBX5

• Protein Name：
• T-box transcription factor TBX5

• Human Gene Id：
• 6910

• Human Swiss Prot No：
• Q99593

• Mouse Swiss Prot No：
• P70326

• Immunogen：
• Purified recombinant fragment of TBX5 expressed in E. Coli.

• Specificity：
• TBX5 Monoclonal Antibody detects endogenous levels of TBX5 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TBX5;T-box transcription factor TBX5;T-box protein 5

• Molecular Weight(Da)：
• 58kD

• References：
• 1. Physiol Genomics. 2004 Jul 8;18(2):129-40.
  2. J Mol Cell Cardiol. 2003 Oct;35(10):1191-5.

• Background：
• This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],

• Function：
• disease:Defects in TBX5 are the cause of Holt-Oram syndrome (HOS) [MIM:142900]. HOS is a developmental disorder affecting the heart and upper limbs. It is characterized by thumb anomaly and atrial septal defects.,function:Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation.,similarity:Contains 1 T-box DNA-binding domain.,

• Subcellular Location：
• Nucleus . Cytoplasm . Shuttles between the cytoplasm and the nucleus. Acetylation at Lys-339 promotes nuclear retention. .

• Expression：
• Lung,Spleen,

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