• Target：
• TLR2

• Fields：
• >>Phagosome;>>PI3K-Akt signaling pathway;>>Neutrophil extracellular trap formation;>>Toll-like receptor signaling pathway;>>Salmonella infection;>>Legionellosis;>>Leishmaniasis;>>Chagas disease;>>Malaria;>>Toxoplasmosis;>>Amoebiasis;>>Tuberculosis;>>Hepatitis B;>>Measles;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Human immunodeficiency virus 1 infection;>>Coronavirus disease - COVID-19;>>Proteoglycans in cancer;>>PD-L1 expression and PD-1 checkpoint pathway in cancer;>>Inflammatory bowel disease;>>Rheumatoid arthritis;>>Lipid and atherosclerosis

• Gene Name：
• TLR2

• Protein Name：
• Toll-like receptor 2

• Human Gene Id：
• 7097

• Human Swiss Prot No：
• O60603

• Mouse Swiss Prot No：
• Q9QUN7

• Immunogen：
• Purified recombinant fragment of human TLR2 expressed in E. Coli.

• Specificity：
• TLR2 Monoclonal Antibody detects endogenous levels of TLR2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TLR2;TIL4;Toll-like receptor 2;Toll/interleukin-1 receptor-like protein 4;CD antigen CD282

• Molecular Weight(Da)：
• 90kD

• References：
• 1. Ginekol Pol. 2009 Dec;80(12):914-9. Polish.
  2. BMC Med Genet. 2010 Mar 2;11:37.

• Background：
• The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],

• Function：
• function:Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.,polymorphism:Genetic variations in TLR2 are associated with suceptibility to leprosy [MIM:246300]. Leprosy is a chronic disease associated with depressed cellular (but not humoral) immunity, the bacterium requires a lower temperature than 37 degrees Celsius and thrives par

• Subcellular Location：
• Membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, phagosome membrane ; Single-pass type I membrane protein . Membrane raft . Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determines the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers. .

• Expression：
• Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.

Ambient fine particulate matter induces inflammatory responses of vascular endothelial cells through activating TLR-mediated pathway:. TOXICOLOGY AND INDUSTRIAL HEALTH Toxicol Ind Health. 2019;35(10):670-678 WB Mouse,Human aortas HUVECs

Galectin from Trichinella spiralis alleviates DSS-induced colitis in mice by regulating the intestinal microbiota VETERINARY RESEARCH Li Jianqing WB Mouse 1:1000 colon tissue

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