TBL1XR1 Monoclonal Antibody

    • Catalog No.：YM1102
    • Applications：WB;IHC;IF
    • Reactivity：Human;Mouse;Rat;Bovine;Chicken;Dog;Pig;Zebrafish
      • Target：
      • TBLR1
      • Fields：
      • >>Wnt signaling pathway
      • Gene Name：
      • TBL1XR1
      • Protein Name：
      • F-box-like/WD repeat-containing protein TBL1XR1
      • Human Swiss Prot No：
      • Q9BZK7
      • Mouse Swiss Prot No：
      • Q8BHJ5
      • Immunogen：
      • Purified recombinant human TBL1XR1 protein fragments expressed in E.coli.
      • Specificity：
      • TBL1XR1 Monoclonal Antibody detects endogenous levels of TBL1XR1 protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • WB 1:1000 - 1:2000. IHC 1:500 - 1:1000. IF 1:100 - 1:500. Not yet tested in other applications.
      • Purification：
      • Affinity purification
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • TBL1XR1;IRA1;TBLR1;F-box-like/WD repeat-containing protein TBL1XR1;Nuclear receptor corepressor/HDAC3 complex subunit TBLR1;TBL1-related protein 1;Transducin beta-like 1X-related protein 1
      • Molecular Weight(Da)：
      • 56kD
      • Background：
      • This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016],
      • Function：
      • domain:The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.,function:F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the WD repeat EBI family.,similarity:Contains 1 F-box-like domain.,similarity:Contains 1 LisH domain.,simi
      • Subcellular Location：
      • Nucleus .
      • Expression：
      • Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver.
      • Products Images
      • Western Blot analysis using TBL1XR1 Monoclonal Antibody against mouse brain, mouse heart, K562 cell lysate.
      • Immunohistochemistry analysis of paraffin-embedded huma breast cancer using TBL1XR1 Monoclonal Antibody.
      • Immunofluorescence analysis of HeLa cells using TBL1XR1 Monoclonal Antibody.

      Attributes

      • Code：
      • YM1102
      • Size
      • 50μL / 100μL / 200μL
      • Price$：
      • 210 / 350 / 600
      • Delivery：
      • 2024-05-09
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