• Target：
• Kif 7

• Fields：
• >>Hedgehog signaling pathway;>>Pathways in cancer;>>Basal cell carcinoma

• Gene Name：
• KIF7

• Protein Name：
• Kinesin-like protein KIF7

• Human Gene Id：
• 374654

• Human Swiss Prot No：
• Q2M1P5

• Mouse Gene Id：
• 16576

• Mouse Swiss Prot No：
• B7ZNG0

• Immunogen：
• Synthetic Peptide of Kif 7

• Specificity：
• The antibody detects endogenous Kif 7 proteins.

• Formulation：
• PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

• Source：
• Monoclonal, Mouse

• Dilution：
• IHC 1:50-200. IF 1:50-200

• Purification：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Kinesin-like protein KIF7

• Background：
• This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies. [provided by RefSeq, Oct 2011],

• Function：
• similarity:Belongs to the kinesin-like protein family. KIF27 subfamily.,similarity:Contains 1 kinesin-motor domain.,tissue specificity:Embryonic stem cells, melanotic melanoma and Jurkat T-cells.,

• Subcellular Location：
• Cell projection, cilium . Cytoplasm, cytoskeleton, cilium basal body . Localizes to the cilium tip.

• Expression：
• Embryonic stem cells, melanotic melanoma and Jurkat T-cells. Expressed in heart, lung, liver, kidney, testis, retina, placenta, pancreas, colon, small intestin, prostate and thymus.

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