• Target：
• P21

• Gene Name：
• CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1

• Protein Name：
• p21

• Human Gene Id：
• 1026

• Human Swiss Prot No：
• P38936

• Mouse Gene Id：
• 12575

• Mouse Swiss Prot No：
• P39689

• Immunogen：
• Synthesized peptide derived from human p21 AA range: 1-100

• Specificity：
• This antibody detects endogenous levels of p21 protein.

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Mouse, Monoclonal/IgG1, kappa

• Dilution：
• IHC 1:200-1000. WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000

• Purification：
• Protein G

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Cyclin-dependent kinase inhibitor 1 ;CDK-interacting protein 1;Melanoma differentiation-associated protein 6;MDA-6;p21;

• Molecular Weight(Da)：
• 21kD

• Observed Band(KD)：
• 21kD

• Function：
• function:May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.,induction:By p53, mezerein (antileukemic compound) and interferon beta.,PTM:Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.,similarity:Belongs to the CDI family.,tissue specificity:Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.,

• Subcellular Location：
• Cytoplasmic, Nuclear

• Expression：
• Expressed in all adult tissues, with 5-fold lower levels observed in the brain.

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