• Target：
• c-Fos

• Fields：
• >>Endocrine resistance;>>MAPK signaling pathway;>>cAMP signaling pathway;>>Apoptosis;>>Osteoclast differentiation;>>Toll-like receptor signaling pathway;>>IL-17 signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>T cell receptor signaling pathway;>>B cell receptor signaling pathway;>>TNF signaling pathway;>>Circadian entrainment;>>Cholinergic synapse;>>Dopaminergic synapse;>>Estrogen signaling pathway;>>Prolactin signaling pathway;>>Oxytocin signaling pathway;>>Relaxin signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>Non-alcoholic fatty liver disease;>>Growth hormone synthesis, secretion and action;>>Amphetamine addiction;>>Pathogenic Escherichia coli infection;>>Salmonella infection;>>Pertussis;>>Yersinia infection;>>Leishmaniasis;>>Chagas disease;>>Hepatitis B;>>Measles;>>Human T-cell leukemia virus 1 infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Human immunodeficiency virus 1 infection;>>Coronavirus disease - CO

• Gene Name：
• FOS

• Protein Name：
• Proto-oncogene c-Fos

• Human Gene Id：
• 2353

• Human Swiss Prot No：
• P01100

• Mouse Gene Id：
• 14281

• Mouse Swiss Prot No：
• P01101

• Rat Gene Id：
• 140675

• Rat Swiss Prot No：
• P12841

• Immunogen：
• AA range: 200-300

• Specificity：
• This antibody detects endogenous levels of C-Fos protein.

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Mouse, Monoclonal

• Dilution：
• WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000;

• Purification：
• The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• FOS;G0S7;Proto-oncogene c-Fos;Cellular oncogene fos;G0/G1 switch regulatory protein 7

• Molecular Weight(Da)：
• 40kD

• Observed Band(KD)：
• 62kD

• Background：
• The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008],

• Function：
• function:Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, c-fos and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.,PTM:Constitutively sumoylated by SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-232.,PTM:Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Phosphorylated, in vitro, by MAPK and RSK

• Subcellular Location：
• Nucleus, Cytoplasm

• Expression：
• Lung adenocarcinoma,Pancreas,Tongue,

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