• Target：
• PD1

• Fields：
• >>Cell adhesion molecules;>>T cell receptor signaling pathway;>>PD-L1 expression and PD-1 checkpoint pathway in cancer

• Gene Name：
• PDCD1 PD1

• Protein Name：
• Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)

• Human Gene Id：
• 5133

• Human Swiss Prot No：
• Q15116

• Immunogen：
• Synthesized peptide derived from human PD-1 AA range: 1-100

• Specificity：
• The antibody can specifically recognize human PD-1 protein.

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Mouse, Monoclonal/IgG1, kappa

• Dilution：
• IHC 1:200-1000. WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000

• Purification：
• Protein G

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CD279；CD279 antigen；hPD 1；hPD l；hPD-1；hSLE1；PD 1；PD-1；PD1；PDCD 1；PDCD1；PDCD1_HUMAN；Programmed cell death 1；Programmed cell death 1 protein；Programmed cell death protein 1；Protein PD 1；Protein PD-1；SLEB2；Systemic lupus erythematosus susceptibility 2

• Molecular Weight(Da)：
• 32kD

• Observed Band(KD)：
• 56kD

• Background：
• Programmed death-1 (PD-1) is an important immunosuppressive molecule. It is a member of CD28 superfamily. It is mainly expressed in germinal center related helper T cells and CD8 positive T cells. It includes tyrosine based inhibitory motif immune receptors, and plays an important role in peripheral immune tolerance mechanism and autoimmune diseases. PD-1 is a receptor for PD-L1 and PD-L2. Immune regulation targeting PD-1 is of great significance in anti-tumor, anti infection, anti autoimmune diseases and organ transplantation survival.

• Function：
• developmental stage:Induced at programmed cell death.,disease:Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,function:Possible cell death inducer, in association with other factors.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Monomer.,

• Subcellular Location：
• Membranous, Cytoplasmic

• Expression：
• Placenta,Pooled tissue,Uterine cervix,

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