Insulin (ABT-INS) mouse mAb (Ready to Use)

    • Catalog No.:YM6121R
    • Applications:IHC
    • Reactivity:Human; Mouse;(predicted: Rat)
      • Target:
      • Insulin
      • Fields:
      • >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>cGMP-PKG signaling pathway;>>HIF-1 signaling pathway;>>FoxO signaling pathway;>>Phospholipase D signaling pathway;>>Oocyte meiosis;>>Autophagy - animal;>>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>Regulation of actin cytoskeleton;>>Insulin signaling pathway;>>Insulin secretion;>>Ovarian steroidogenesis;>>Progesterone-mediated oocyte maturation;>>Prolactin signaling pathway;>>Regulation of lipolysis in adipocytes;>>Type II diabetes mellitus;>>Insulin resistance;>>Non-alcoholic fatty liver disease;>>Type I diabetes mellitus;>>Maturity onset diabetes of the young;>>Aldosterone-regulated sodium reabsorption;>>Alzheimer disease;>>Prostate cancer;>>Diabetic cardiomyopathy
      • Gene Name:
      • INS
      • Protein Name:
      • Insulin [Cleaved into: Insulin B chain; Insulin A chain]
      • Human Gene Id:
      • 3630
      • Human Swiss Prot No:
      • P01308
      • Immunogen:
      • Synthesized peptide derived from human Insulin AA range: 25-110
      • Specificity:
      • This antibody detects endogenous levels of human Insulin. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Mouse, Monoclonal/IgG2b, Kappa
      • Dilution:
      • Ready to use for IHC
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Storage Stability:
      • 2°C to 8°C/1 year
      • Background:
      • After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010],
      • Function:
      • disease:Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].,function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.,function:Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.,function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.,mass spectrometry: PubMed:12586351; PubMed:15359740,online information:Clinical information on Eli Lilly insu
      • Subcellular Location:
      • Cytoplasmic
      • Expression:
      • Blood,Liver,Muscle,Pancreas,
      • Products Images
      • Human pancreas tissue was stained with Anti-Insulin (ABT-INS) Antibody
      • Human pancreas tissue was stained with Anti-Insulin (ABT-INS) Antibody