Neurofilament (ABT456) mouse mAb (Ready to Use)

  • Catalog No.：YM6897R
  • Applications：IHC
  • Reactivity：Human;Mouse;Rat;
    • Target：
    • NF-L
    • Fields：
    • >>Amyotrophic lateral sclerosis;>>Pathways of neurodegeneration - multiple diseases
    • Gene Name：
    • NEFL NF68 NFL
    • Protein Name：
    • Neurofilament
    • Human Gene Id：
    • 4747
    • Human Swiss Prot No：
    • P07196
    • Immunogen：
    • Synthesized peptide derived from human Neurofilament AA range: 400-543
    • Specificity：
    • The antibody can specifically recognize human Neurofilament protein, especilaly NF-L protein.
    • Formulation：
    • The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
    • Source：
    • Mouse, Monoclonal/IgG1, kappa
    • Dilution：
    • Ready to use for IHC
    • Purification：
    • The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
    • Storage Stability：
    • 2°C to 8°C/1 year
    • Other Name：
    • Neurofilament light polypeptide (NF-L;68 kDa neurofilament protein;Neurofilament triplet L protein)
    • Background：
    • Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008],
    • Function：
    • caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 1F (CMT1F) [MIM:607734]. CMT1F is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. CMT1F is charac
    • Subcellular Location：
    • Cytoplasmic
    • Expression：
    • Cytoplasmic

    Attributes

    • Code：
    • YM6897R
    • Size
    • 3mL / 6mL / 10mL
    • Price$：
    • 120 / 180 / 240
    • Delivery：
    • 2024-11-23
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