PAX-8 (PT0042R) rabbit mAb

  • Catalog No.：YM8013
  • Applications：IHC;ELISA
  • Reactivity：Human;
    • Target：
    • Pax-8
    • Fields：
    • >>Thyroid hormone synthesis;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Thyroid cancer
    • Gene Name：
    • PAX8
    • Protein Name：
    • Paired box protein Pax-8
    • Human Gene Id：
    • 7849
    • Human Swiss Prot No：
    • Q06710
    • Mouse Swiss Prot No：
    • Q00288
    • Immunogen：
    • Synthesized peptide derived from human protein. AA range:150-250
    • Specificity：
    • endogenous
    • Formulation：
    • PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
    • Source：
    • Monoclonal Rabbit IgG1, Kappa
    • Dilution：
    • IHC 1:100-500 ELISA: 1:20000
    • Purification：
    • Protein A
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • PAX8;Paired box protein Pax-8
    • Background：
    • This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010],
    • Function：
    • caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,developmental stage:In developing excretory system, during thyroid differentiation and in adult thyroid.,disease:Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) [MIM:218700]. CHNG2 is a disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.,function:Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cell
    • Subcellular Location：
    • Nuclear
    • Expression：
    • Expressed in the excretory system, thyroid gland and Wilms tumors.

    Attributes

    • Code：
    • YM8013
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-08-16
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