• Target：
• HSP90B

• Fields：
• >>Protein processing in endoplasmic reticulum;>>PI3K-Akt signaling pathway;>>Necroptosis;>>Antigen processing and presentation;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>Th17 cell differentiation;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Salmonella infection;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Prostate cancer;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis

• Gene Name：
• HSP90AB1

• Protein Name：
• Heat shock protein HSP 90-beta

• Human Gene Id：
• 3326

• Human Swiss Prot No：
• P08238

• Mouse Gene Id：
• 15516

• Mouse Swiss Prot No：
• P11499

• Rat Gene Id：
• 301252

• Rat Swiss Prot No：
• P34058

• Specificity：
• endogenous

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, rabbit, IgG, Kappa

• Dilution：
• IHC 1:200-1000,WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

• Purification：
• Protein A

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• HSP90AB1;HSP90B;HSPC2;HSPCB;Heat shock protein HSP 90-beta;HSP 90;Heat shock 84 kDa;HSP 84;HSP84

• Molecular Weight(Da)：
• 85kD

• Observed Band(KD)：
• 85kD

• Background：
• This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012],

• Function：
• function:Molecular chaperone. Has ATPase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with TP53/p53 (By similarity). Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer.,

• Subcellular Location：
• Cytoplasm, Nuclear

• Expression：
• Amygdala,Brain cortex,Colon,Colon carcinoma,Embryon

Metabolites profiling and pharmacokinetics of troxipide and its pharmacodynamics in rats with gastric ulcer. Scientific Reports Sci Rep-Uk. 2020 Aug;10(1):1-21 IHC Rat Stomach

Correlation between nuclear expression of heat shock protein 90 in dermis and glucocorticoid resistance in bullous dermatosis STEROIDS Wenqing Wang IF Human epidermis

A novel multifunctional microneedle patch for synergistic photothermal- gas therapy against maxillofacial malignant melanoma and associated skin defects JOURNAL OF NANOBIOTECHNOLOGY Shaojie Dong WB Mouse 1:2000 novel multifunctional sodium nitroprusside and Fe2+ ions loaded microneedles (SNP-Fe@MNs)

Involvement of circRNA Regulators MBNL1 and QKI in the Progression of Esophageal Squamous Cell Carcinoma Cancer Control Hai-Feng Wang WB Human 1:2000 KYSE150 cell

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