• Target：
• MMP-3

• Fields：
• >>IL-17 signaling pathway;>>TNF signaling pathway;>>Coronavirus disease - COVID-19;>>Transcriptional misregulation in cancer;>>Prostate cancer;>>Rheumatoid arthritis;>>Lipid and atherosclerosis

• Gene Name：
• MMP3

• Protein Name：
• Stromelysin-1

• Human Gene Id：
• 4314

• Human Swiss Prot No：
• P08254

• Mouse Gene Id：
• 17392

• Mouse Swiss Prot No：
• P28862

• Rat Swiss Prot No：
• P03957

• Specificity：
• endogenous

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, rabbit, IgG, Kappa

• Dilution：
• IHC 1:200-1:1000,WB 1:1000-1:5000,IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200,

• Purification：
• Protein A

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MMP3;STMY1;Stromelysin-1;SL-1;Matrix metalloproteinase-3;MMP-3;Transin-1

• Molecular Weight(Da)：
• 54kD

• Observed Band(KD)：
• 54kD

• Background：
• matrix metallopeptidase 3(MMP3) Homo sapiens Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:Preferential cleavage where P1', P2' and P3' are hydrophobic residues.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 4 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,

• Subcellular Location：
• Cytoplasm

• Expression：
• Fibroblast,Lung,Synovium,

Transglutaminase 2 inhibitors attenuate osteoarthritic degeneration of TMJ-osteoarthritis by suppressing NF-κB activation INTERNATIONAL IMMUNOPHARMACOLOGY Yanyan Li, Huifang Sun, Xin Liu, Zhihui Hu, Henghua Jiang, Huilin Guo, Xing Long WB, IHC Mouse, Rat TMJ tissue ATDC5 cell

17β-Estradiol alleviates intervertebral disc degeneration by inhibiting NF-κB signal pathway. LIFE SCIENCES Life Sci. 2021 Nov;284:119874 IHC Rat 1:200 Interverbal disc (IVD)

CX3CL1 promotes tumour cell by inducing tyrosine phosphorylation of cortactin in lung cancer. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE J Cell Mol Med. 2021 Jan;25(1):132-146 IHC,WB Human,Mouse 1:300,1:1000 A549-Xenograft，Lung A549 cell

Administration of SB203580, a p38 MAPK Inhibitor, Reduced the Expression of MMP9, and Relieved Neurologic Severity in the Experimental Autoimmune Neuritis (EAN) in Rats. NEUROCHEMICAL RESEARCH Neurochem Res. 2015 Jul;40(7):1410-1420 WB Rat 1:750 sciatic nerves

Integrated transcriptome and proteome revealed that the declined expression of cell cycle-related genes associated with follicular atresia in geese BMC GENOMICS Xingyong Chen WB Geese follicles

The Effects of Injectable Platelet-Rich Fibrin and Advanced-Platelet Rich Fibrin on Gingival Fibroblast Cell Vitality, Proliferation, Differentiation. Tissue Engineering and Regenerative Medicine Yin Lihua WB Human 1:1000 human gingival fibroblast cells (HGFCs)

Koumine inhibits IL-1β-induced chondrocyte inflammation and ameliorates extracellular matrix degradation in osteoarthritic cartilage through activation of PINK1/Parkin-mediated mitochondrial autophagy BIOMEDICINE & PHARMACOTHERAPY Xiangyi Kong WB Rat RCCS-1 cell

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